
Dogs of all breeds are vulnerable to infestations of internal and external parasites. The pesky organisms attack our furry babies, causing discomfort or even serious damage to their organs. Therefore, it becomes crucial for dog parents to use efficient parasite treatments to keep their canines safe and parasite-free. Thankfully, there is a plethora of multi-parasite treatments available on the market that work excellently to keep parasites at bay. Two such products that have gained immense popularity among dog parents are Simparica Trio and Advantage Multi.
In this blog, we will offer a detailed comparison between the two remedies to help you choose the treatment that perfectly meets your dog’s requirements. Let’s get started.
Simparica Trio vs. Advantage Multi – A Quick Glance
Simparica Trio for Dogs
Simparica Trio comes in the form of a pork liver-flavored chew indicated to prevent heartworm disease caused by Dirofilariaimmitis and treat and control roundworm and hookworm infections. The treatment also kills adult fleas and treats and prevents flea infestations.
It further treats and controls tick infestations caused by lone star ticks, Gulf Coast ticks, American dog ticks, black-legged ticks, brown dog ticks and Asian long horned ticks for one month. Additionally, the treatment is recommended for the prevention of Lyme disease infections due to the direct result of killing black-legged ticks. It is suitable for dogs and puppies from 8 weeks of age, weighing at least 2.8 lbs.
Also Read: Everything You Need to Know About the All-New Simparica Trio
Advantage Multi for Dogs
Advantage Multi is a monthly topical treatment for dogs formulated to prevent heartworm disease caused by Dirofilariaimmitis and treat circulating microfilariae in heartworm-positive canines. The treatment also kills adult fleas and treats flea infestations. It also treats and controls sarcoptic mange and gastrointestinal worms such as hookworms, roundworms and whipworms. The remedy is suitable for dogs and puppies from 7 weeks of age, weighing at least 3 lbs.
Simparica Trio and Advantage Multi – Similarities and Differences
Here are the key similarities and differences between Simparica Trio and Advantage Multi.
Similarities
- Both Simparica Trio and Advantage Multi kill adult fleas and treat and prevent flea infestations.
- Each of them prevents heartworm disease caused by Dirofilariaimmitis.
- Both treatments treat and control roundworm and hookworm infections.
- Both Simparica Trio and Advantage Multi offer parasite protection for one month.
- The safe use of both Simparica Trio and Advantage Multi has not been evaluated in breeding, pregnant and lactating dogs.
Differences
- While Simparica Trio is an oral treatment, Advantage Multi is formulated for topical administration.
- Simparica Trio is meant for dogs and puppies from 8 weeks of age. However, Advantage Multi is designed for canines from 7 weeks.
- Simparica Trio is suitable for dogs and puppies from 2.8 lbs of body weight. But Advantage Multi is formulated for canines weighing at least 3 lbs.
- While Simparica Trio is composed of sarolaner, moxidectin and pyrantel as its active ingredients, Advantage Multi contains imidacloprid and moxidectin.
- Simparica Trio protects against tick species like lone star ticks, Gulf Coast ticks, American dog ticks, black-legged ticks, brown dog ticks and Asian long horned ticks. However, Advantage Multi doesn’t protect dogs against ticks.
- Advantage Multi treats and controls whipworms and Sarcoptic Mange. Simparica Trio has no such claims.
- Simparica Trio prevents Lyme disease infections by killing black-legged ticks. However, Advantage Multi doesn’t.
A Detailed Comparison
The following table provides a detailed comparison between the key features of Simparica Trio and Advantage Multi.

Concluding Note
Both Simparica Trio and Advantage Multi are vet-recommended treatments formulated to protect canines against various internal and external parasites. However, they differ when it comes to parasite coverage, composition, mode of administration, as well as age and weight criteria.
If you want protection against fleas, heartworm disease and intestinal worms like hookworms and roundworms, either of the products can be used. However, if you are seeking protection against ticks like lone star ticks, Gulf Coast ticks, American dog ticks, black-legged ticks, brown dog ticks and Asian longhorned ticks, you should go for Simparica Trio. For protection against whipworms and sarcoptic mange, you should opt for Advantage Multi.
Simparica Trio and Advantage Multi are available on BestVetCare at discounted prices. Check out our online store to enjoy unbeatable deals on your preferred treatments from the comfort of your home.