Simparica Trio vs. Heartgard Plus: A Detailed Comparative Analysis

By | June 4, 2024
Simparica trio vs Heartgard Plus

Parasitic worms are a big reason to worry for any canine parent. Heartworms and intestinal worms such as roundworms, hookworms, etc. are more than harmful to our animal love. And if fleas and ticks like external parasites accompany them, God bless our animal children! So, what do we do? Give them the best possible protection. Simparica Trio and Heartgard Plus are a couple of high-quality parasitic treatments for dogs that protect dogs against a range of parasites. But which one should you use?

This blog gives you a comparative analysis of these two popular dog treatments so that you can shortlist one for your canine love. Dive in to learn more.

Simparica Trio & Heartgard Plus – Product Overview

Simparica Trio for Dogs protects puppies and dogs against a range of external and internal parasites for one month. This all-in-one treatment is formed in a palatable liver flavor and indicated for use in 8 weeks and older puppies and dogs, weighing at least 2.8 lbs.

Formulated in a tasty beef-flavored chew, Heartgard Plus for dogs is a multi-worm treatment for 6 weeks and older puppies and dogs. It prevents heartworm disease and protects canines against gastrointestinal worms.

Simparica Trio & Heartgard Plus – Similarities and Differences

Simparica Trio and Heartgard Plus share a few features and have differences at the same time. Let’s have a look at commonalities first.


  • Monthly oral chewable formula

Simparica Trio and Heartgard Plus both are formed in palatable chew form that should be administered orally, once a month.

  • Prevent heartworm disease

When it comes to protecting dogs against heartworms, Simparica Trio and Heartgard Plus both prevent heartworm disease caused by Dirofilaria immitis.

  • Protect against intestinal worms

Simparica Trio and Heartgard Plus for dogs both treat and control roundworm and hookworm infections.


Now, let’s take a look at their uncommon features.

  • Minimum recommended age

Simparica Trio is suitable for dogs from 8 weeks of age, whereas Heartgard Plus is recommended for 6 weeks and older puppies and dogs.

  • Uncommon ingredients

Simparica Trio is formulated with a powerful combination of sarolaner, moxidectin and pyrantel. Heartgard Plus contains ivermectin and pyrantel.

  • Protection against fleas & ticks

Other than protecting against heartworms and intestinal worms, Simparica Trio for dogs kills adult fleas, treats and prevents flea infestations and treats and controls tick infestations caused by lone star tick, Gulf Coast tick, American dog tick, black-legged tick and brown dog tick. Heartgard Plus is not effective against fleas or ticks.

  • Lyme disease prevention

Due to its ability to kill black-legged ticks, Simparica Trio is indicated for the prevention of Lyme disease in dogs. Heartgard Plus is not known to protect against Lyme disease.

Simparica Trio & Heartgard Plus – Comparative Analysis

The table below displays a comparison of product features of Simparica Trio and Heartgard Plus.

Simparica Trio & Heartgard Plus – Comparative Analysis


To summarize, both Simparica Trio and Heartgard Plus are broad-spectrum treatments for dogs.

If you are concerned about your dog’s protection against heartworm disease, roundworms and hookworms, Simparica Trio and Heartgard Plus are equally enabled to do the job. In addition to these worms, to protect your canines against fleas and ticks (specified tick species in the comparison table above) Simparica Trio should be your choice.

The best way to proceed with any broad-spectrum treatment for your pets is only after discussing all the available treatment options with your veterinarian. This is how you’ll ensure the health and happiness of your canine companion.